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Total 20800 results found since Jan 2013.

Extracorporeal Filtration of Potassium in a Swine Model of Bilateral Hindlimb Ischemia-Reperfusion Injury With Severe Acute Hyperkalemia.
Conclusions: We demonstrate that serum potassium can be filtered via hemoperfusion utilizing a simple extracorporeal potassium-binding platform, though evolution of this technology will be required to achieve meaningful reduction of potassium in clinically significant hyperkalemia after trauma. PMID: 30137515 [PubMed - as supplied by publisher]
Source: Military Medicine - August 24, 2018 Category: International Medicine & Public Health Tags: Mil Med Source Type: research

Minimal Invasive Pericardial Perfusion Model in Swine: A Translational Model for Cardiac Remodeling After Ischemia/Reperfusion Injury
ConclusionWe established a minimally invasive, reproducible and translational model of pericardial irrigation in swine. This method enables the investigation of mechanisms involved in myocardial adverse remodeling after ischemia/reperfusion injury in the future.
Source: Frontiers in Physiology - April 21, 2020 Category: Physiology Source Type: research

A Novel Perfusion System for Damage Control of Hyperkalemia in Swine
Conclusions: A simplified hemoperfusion system removed potassium in a porcine model. In austere settings, this system could be used to temporize patients with hyperkalemia until evacuation to a facility with traditional RRT.
Source: Shock - November 14, 2018 Category: Emergency Medicine Tags: Basic Science Aspects Source Type: research

Derivation and validation of a search algorithm to retrospectively identify CRRT initiation in the...
Conclusions: The use of an electronic search strategy resulted in determining an accurate CRRT initiation time among ECMO patients....
Source: Applied Clinical Informatics - June 29, 2016 Category: Information Technology Source Type: research

High-performance information search filters for acute kidney injury content in PubMed, Ovid Medline and Embase
Conclusions PubMed, Ovid Medline and Embase can be filtered for articles relevant to AKI in a reliable manner. These high-performance information filters are now available online and can be used to better identify AKI content in large bibliographic databases.
Source: Nephrology Dialysis Transplantation - March 27, 2014 Category: Urology & Nephrology Authors: Hildebrand, A. M., Iansavichus, A. V., Haynes, R. B., Wilczynski, N. L., Mehta, R. L., Parikh, C. R., Garg, A. X. Tags: Acute Kidney Injury Source Type: research

Newest strategies in the search for bioactive saponins from the tropical plant biodiversity.
Abstract This review will focus on newest results leading to the discovery of new bioactive saponins by using a combination of successive advanced procedures in extraction, isolation, structure elucidation and bioassays. Microwave- and ultrasonic-assisted extractions, two recent advanced methods have been increasingly used in the last decade. Then, a multistep purification procedure was achieved by flash chromatography, vacuum liquid chromatography, low, medium- and high-pressure liquid chromatography on silica gel and reversed-phase silica gel RP-18 (VLC, LPLC, MPLC, HPLC). These successive chromatographic steps ...
Source: Current Drug Delivery - November 1, 2015 Category: Drugs & Pharmacology Authors: Lacaille-Dubois MA Tags: Curr Drug Deliv Source Type: research

Infrapopliteal calcification patterns in critical limb ischemia: diagnostic, pathologic and therapeutic implications in the search for the endovascular holy grail.
This article attempts to review the implications of the diverse pathologic patterns of calcium distribution in infrapopliteal vessels of CLI patients, on the diagnostic modalities, technological developments, and the evolution of therapeutic approaches to improve outcomes among these patients. A critical analysis of the currently available data is provided, pointing to the surprising omission on the role of calcium on outcomes, and future directions are discussed. Is infrapopliteal calcium a roadblock or the avenue towards new paths? Necessity remains the mother of invention. PMID: 28240525 [PubMed - as supplied by publisher]
Source: The Journal of Cardiovascular Surgery - February 26, 2017 Category: Cardiovascular & Thoracic Surgery Authors: Mustapha JA, Diaz-Sandoval LJ, Saab F Tags: J Cardiovasc Surg (Torino) Source Type: research

Beat von Albertini: Lifetime search for increased dialysis treatment efficiency-An obituary.
PMID: 29739308 [PubMed - in process]
Source: The International Journal of Artificial Organs - May 1, 2018 Category: Transplant Surgery Authors: Vienken J, Walpoth B, European Society for Artificial Organs (ESAO) Tags: Int J Artif Organs Source Type: research

Starting Dialysis-Planning for the Unpredictable and the Search for Meaningful Process Measures.
Authors: Wilkie M PMID: 30185476 [PubMed - in process]
Source: Peritoneal Dialysis International - September 7, 2018 Category: Urology & Nephrology Tags: Perit Dial Int Source Type: research

The search for brain-permeant NKCC1 inhibitors for the treatment of seizures: Pharmacokinetic-pharmacodynamic modelling of NKCC1 inhibition by azosemide, torasemide, and bumetanide in mouse brain.
Abstract Because of its potent inhibitory effect on the Na+-K+-2Cl- symporter isotype 1 (NKCC1) in brain neurons, bumetanide has been tested with varying results for treatment of seizures that potentially evolve as a consequence of abnormal NKCC1 activity. However, because of its physicochemical properties, bumetanide only poorly penetrates into the brain. We previously demonstrated that NKCC1 can be also inhibited by azosemide and torasemide, which lack the carboxyl group of bumetanide and thus should be better brain-permeable. Here we studied the brain distribution kinetics of azosemide and torasemide in compari...
Source: Epilepsy and Behaviour - December 2, 2020 Category: Neurology Authors: Hampel P, Römermann K, Gramer M, Löscher W Tags: Epilepsy Behav Source Type: research

Egypt’s Poor Easy Victims of Quack Medicine
Many pharmacies and herbalists in Egypt prescribe their own 'wasfa' (secret drug or herbal elixir). Credit: Cam McGrath/IPSBy Cam McGrathCAIRO, Aug 10 2014 (IPS) Magda Ibrahim first learnt that she had endometrial cancer when she went to a clinic to diagnose recurring bladder pain and an abnormal menstrual discharge. Unable to afford the recommended hospital treatment, the uninsured 53-year-old widow turned to what she hoped would be a quicker and cheaper therapy. A local Muslim sheikh claimed religious incantations, and a suitable donation to his pocket, could cure the cancer. But when her symptoms persisted, Ibrahim cons...
Source: IPS Inter Press Service - Health - August 10, 2014 Category: Global & Universal Authors: Cam McGrath Tags: Civil Society Education Featured Headlines Health Human Rights Middle East & North Africa Poverty & MDGs Projects Women's Health AIDS avian flu blood dialysis clinics Corruption Doctors Egypt Health care Hepatitis C h Source Type: news

Antigen I/II Participates in the Interactions of Streptococcus suis Serotype 9 With Phagocytes and the Development of Systemic Disease
In conclusion, S. suis serotype 9 causes a systemic infection resulting in the development of clinical disease and host death. As with serotype 2, this infection is characterized by exacerbated inflammation induced by an uncontrolled and persistent bacterial presence in the systemic compartment. Not only does presence of AgI/II affect S. suis phagocytosis by promoting resistance to phagocytic cells, but it also participates in innate immune cell activation, and by consequence, inflammation. As such, S. suis serotype 9 AgI/II is an important factor involved in not only the initial steps of its pathogenesis in pigs, but also...
Source: Frontiers in cellular and infection microbiology - April 23, 2019 Category: Microbiology Source Type: research

Aethlon ’ s blood filtration device as broad countermeasure for infectious diseases
In the midst of a devastating global crisis 2 years ago, a Ugandan physician was infected with Ebola in Sierra Leone as he was treating patients. He was hospitalized at the Frankfurt University Hospital and 12 days later he was unconscious, suffering from multiple organ failure. By the time Aethlon Medical (NSDQ:AEMD) got permission to use its Hemopurifier device, the doctor required mechanical ventilation, continuous dialysis and vasopressor medications. After almost 7 hours of treatment with the single cartridge blood filtration device, the patient’s viral load dropped from 400,000 virus copies per milliliter of b...
Source: Mass Device - November 18, 2016 Category: Medical Equipment Authors: Sarah Faulkner Tags: Blood Management Food & Drug Administration (FDA) Research & Development Aethlon Medical Inc. MassDevice Q&A Source Type: news

Exercise training for adults undergoing maintenance dialysis
CONCLUSIONS: It is uncertain whether exercise training improves death, cardiovascular events, or the mental component of HRQoL in adults undergoing maintenance dialysis. Exercise training probably improves depressive symptoms, particularly when the intervention is maintained beyond four months. Exercise training is also likely to improve functional capacity. Low certainty evidence suggested that exercise training may improve fatigue, the physical component of quality of life, and pain. The safety of exercise training for adults undergoing dialysis remains uncertain.PMID:35018639 | PMC:PMC8752366 | DOI:10.1002/14651858.CD014653
Source: Cochrane Database of Systematic Reviews - January 12, 2022 Category: General Medicine Authors: Amelie Bernier-Jean Nadim A Beruni Nicola P Bondonno Gabrielle Williams Armando Teixeira-Pinto Jonathan C Craig Germaine Wong Source Type: research

A Systematic Review of the Health Impacts of Mass Earth Movements (Landslides)
Conclusions and recommendations We conclude that the health impacts of landslides are poorly documented in almost all respects. Causes of death and the nature of injuries suffered in landslides remain almost entirely undocumented in the literature, and there are very few studies of the nature of treatments required by the victims of landslides. A greater level of information is available with respect to the psychiatric impacts. These studies show that the effects are more substantial than for other types of natural hazards. Probably, this reflects the violence of landslides, but even this evidence is limited. Consequentl...
Source: PLOS Currents Disasters - April 30, 2015 Category: Global & Universal Authors: iaintrk Source Type: research